5-Amino-1MQ is the #1 NNMT inhibitor for serious athletes – zero stimulant side effects. It raises NAD⁺ levels, activates SIRT1/SIRT3 and optimizes GLUT4 translocation. Result: fat loss + maximum muscle retention during cut, recomp or peak week.

What is 5-Amino-1MQ?

Derivative of 1-methylquinolinium → highly selective NNMT inhibitor. Primary target: white adipocytes → NAD⁺ ↑ → massively improved metabolic flexibility.

NNMT – The Hidden Enzyme That Sabotages Metabolism

NNMT methylates nicotinamide → NAD⁺ ↓. In overweight individuals NNMT is upregulated → energy ↓, fat storage ↑. Inhibiting NNMT = NAD⁺ surge → Sirtuin activation + mitochondrial biogenesis.

NAD⁺ – The Master Regulator of Energy & Longevity

Co-factor in over 500 reactions → ETC, Sirtuins, PARP. Higher NAD⁺ = more ATP, faster recovery, genomic stability.

Sirtuins: SIRT1 & SIRT3 Activation

5-Amino-1MQ → NAD⁺ ↑ → SIRT1/SIRT3 massively upregulated:

• Muscle preservation in deep caloric deficit
• Mitochondrial biogenesis ↑
• Systemic inflammation ↓ (NF-κB)

GLUT4 & Superior Glucose Partitioning

5-Amino-1MQ → GLUT4 expression & translocation ↑ → glucose shuttled into muscle instead of fat storage. Insulin sensitivity skyrockets → perfect recomp tool.

Compared to Metformin, Berberine & Co.

Application in Bodybuilding & Fasting

• 🔹 Cut: Muscle protection, faster recovery, zero cravings
• 🔹 Recomp: Harder look, higher energy, perfect carb partitioning
• 🔹 Fasting: NAD⁺/SIRT1 synergy → massive autophagy boost

Dosage & Stacking Protocols

• Dosage: 25–50 mg daily (morning, fasted or with meal)
• Cycle: 4–8 weeks on, 2–4 weeks off
• Stack examples:
  • Testosterone → lean mass retention in deficit
  • SARMs (e.g. RAD-140) → insane recomp
  • HGH → mitochondrial fat oxidation
  • Natural / PCT → completely non-suppressive

Real Athlete Feedback

Side Effects & Safety Profile

• Zero hormonal suppression
• No stimulant effects → no crash or jitters
• No toxicity at physiological doses
• Avoid during pregnancy / renal insufficiency